This work is licensed under a Creative Commons Attribution 4. The risk in food security is also aggravated by climate change and land degradation, which compromise agricultural productivity. In recent years, our understanding of the role of microbial communities on ecosystem functioning, including plant-associated microbes, has advanced considerably. Yet, translating this knowledge into practical agricultural technologies is challenged by the intrinsic complexity of agroecosystems. Here, we review current strategies for plant microbiome manipulation, classifying them into three main pillars: i introducing and engineering microbiomes, ii breeding and engineering the host plant, and iii selecting agricultural practices that enhance resident soil and plant-associated microbial communities. In each of these areas, we analyze current trends in research, as well as research priorities and future perspectives. Keywords: phytobiome , endosphere , rhizosphere , agroecosystems , sustainability. The increase in global food consumption is placing unprecedented demands on agriculture and natural resources. For that reason, agriculture demands innovative and practices that promote and restore ecosystem health while securing food production. In the last decades, several studies began to acknowledge the key role of microorganisms in natural and managed ecosystems Hardoim et al.

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